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authFullName_s : Christophe Guignabert
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Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation

David Montani , Barbara Girerd , Xavier Jaïs , Pierantonio Laveneziana , Edmund M T Lau , et al.
European Respiratory Journal, In press, ⟨10.1183/13993003.04229-2020⟩
Journal articles hal-03104056v1
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Additive Protective Effects of Sacubitril/Valsartan and Bosentan on Vascular Remodeling in Experimental Pulmonary Hypertension

Marie-Camille Chaumais , Mohamed Reda Amar Djessas , Raphaël Thuillet , Amélie Cumont , Ly Tu , et al.
Cardiovascular Research, 2020, pp.cvaa200. ⟨10.1093/cvr/cvaa200⟩
Journal articles inserm-02907132v1
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Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension

Zongye Cai , Theo Klein , Laurie Geenen , Ly Tu , Siyu Tian , et al.
Journal of Clinical Medicine, 2020, 9 (5), pp.1248. ⟨10.3390/jcm9051248⟩
Journal articles inserm-02581568v1

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension

Marine Germain , Mélanie Eyries , David Montani , Odette Poirier , Barbara Girerd , et al.
Nature Genetics, 2013, 45 (5), pp.518-521. ⟨10.1038/ng.2581⟩
Journal articles hal-02565627v1
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Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension

Ly Tu , Agnes Desroches-Castan , Christine Mallet , Laurent Guyon , Amélie Cumont , et al.
Circulation Research, 2019, 124 (6), pp.846-855. ⟨10.1161/CIRCRESAHA.118.313356⟩
Journal articles inserm-02581297v1
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CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury

Matthieu Leuillier , Thomas Duflot , Séverine Ménoret , Hind Messaoudi , Zoubir Djerada , et al.
International journal of advanced research, 2022, 43, pp.163-174. ⟨10.1016/j.jare.2022.03.004⟩
Journal articles hal-03836917v1
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AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery

Heba Abdelazeem , Ly Tu , Raphaël Thuillet , Mina Ottaviani , Achraf Boulfrad , et al.
European Journal of Pharmacology, 2023, 946, pp.175579. ⟨10.1016/j.ejphar.2023.175579⟩
Journal articles inserm-04058680v1

Telomere Maintenance Is a Critical Determinant in the Physiopathology of Pulmonary Hypertension

Mohamed Izikki , Eric Hoang , Irena Draskovic , Olaf Mercier , Florence Lecerf , et al.
Journal of the American College of Cardiology, 2015, 66 (17), pp.1942 - 1943. ⟨10.1016/j.jacc.2015.08.869⟩
Journal articles hal-01764142v1
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Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension.

Laurence Dewachter , Serge Adnot , Christophe Guignabert , Ly Tu , Elisabeth Marcos , et al.
European Respiratory Journal, 2009, 34 (5), pp.1100-10. ⟨10.1183/09031936.00183008⟩
Journal articles inserm-00433927v1
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Serum and Pulmonary Uric Acid in Pulmonary Arterial Hypertension

Laurent Savale , Satoshi Akagi , Ly Tu , Amélie Cumont , Raphaël Thuillet , et al.
European Respiratory Journal, 2021, 58 (2), pp.2000332. ⟨10.1183/13993003.00332-2020⟩
Journal articles inserm-03118201v1
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Multiple roles of macrophage migration inhibitory factor in pulmonary hypertension

Gael Jalce , Christophe Guignabert
American Journal of Physiology - Lung Cellular and Molecular Physiology, 2020, 318 (1), pp.L1-L9. ⟨10.1152/ajplung.00234.2019⟩
Journal articles inserm-02454988v1
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Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure

Edda Spiekerkoetter , Elena Goncharova , Christophe Guignabert , Kurt Stenmark , Grazyna Kwapiszewska , et al.
Pulmonary circulation / Pulm Circ, 2019, 9 (4), pp.204589401988977. ⟨10.1177/2045894019889775⟩
Journal articles inserm-02612634v1
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Cibler les ligands du récepteur de l’activine de type IIA pour traiter l’hypertension artérielle pulmonaire

Marc Humbert , David Montani , Laurent Savale , Ly Tu , Christophe Guignabert
Médecine/Sciences, 2021, 37 (10), pp.839-843. ⟨10.1051/medsci/2021131⟩
Journal articles hal-03379128v1
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Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension.

Ly Tu , Laurence Dewachter , Benoit Gore , Elie Fadel , Philippe Dartevelle , et al.
American Journal of Respiratory Cell and Molecular Biology, 2011, 45 (2), pp.311-22. ⟨10.1165/rcmb.2010-0317OC⟩
Journal articles inserm-00579959v1

ACE2 as therapy for pulmonary arterial hypertension: the good outweighs the bad

Christophe Guignabert , Frances S de Man , Marc M. Lombès
European Respiratory Journal, 2018, 51 (6), pp.1800848. ⟨10.1183/13993003.00848-2018⟩
Journal articles inserm-02582393v1
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Regulatory T Cell Dysfunction in Idiopathic, Heritable and Connective Tissue-Associated Pulmonary Arterial Hypertension

Alice Huertas , Carole Phan , Jennifer Bordenave , Ly Tu , Raphaël Thuillet , et al.
Chest, 2016, 149 (6), pp.1482-1493. ⟨10.1016/j.chest.2016.01.004⟩
Journal articles inserm-02593143v1
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New Mutations and Pathogenesis of Pulmonary Hypertension: Progress and Puzzles in Disease Pathogenesis

Micheala Aldred , Nicholas Morrell , Christophe Guignabert
Circulation Research, 2022, 130 (9), pp.1365-1381. ⟨10.1161/CIRCRESAHA.122.320084⟩
Journal articles inserm-03654919v1
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Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells

Benjamin Le Vely , Carole Phan , Nihel Berrebeh , Raphaël Thuillet , Mina Ottaviani , et al.
American Journal of Respiratory Cell and Molecular Biology, 2022, Online ahead of print. ⟨10.1165/rcmb.2021-0332oc⟩
Journal articles inserm-03678207v1
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Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex

Morane Le Hiress , Ly Tu , Nicolas Ricard , Carole Phan , Raphaël Thuillet , et al.
American Journal of Respiratory and Critical Care Medicine, 2015, 192 (8), pp.983-997. ⟨10.1164/rccm.201402-0322OC⟩
Journal articles inserm-02579320v1
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Therapeutic effect of pirfenidone in the sugen/hypoxia rat model of severe pulmonary hypertension

Paul-Benoit Poble , Carole Phan , Timothée Quatremare , Jennifer Bordenave , Raphaël Thuillet , et al.
FASEB Journal, 2018, 33 (3), pp.3670-3679. ⟨10.1096/fj.201801659R⟩
Journal articles inserm-02581079v1

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

Marc Humbert , Christophe Guignabert , Sébastien Bonnet , Peter Dorfmüller , James Klinger , et al.
European Respiratory Journal, 2019, 53 (1), pp.1801887. ⟨10.1183/13993003.01887-2018⟩
Journal articles inserm-02612658v1

Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models

Cindy Orvain , Anne Cauvet , Alexis Prudent , Christophe Guignabert , Raphaël Thuillet , et al.
Arthritis Research & Therapy, 2022, 24 (1), pp.13. ⟨10.1186/s13075-021-02709-2⟩
Journal articles hal-03985048v1

Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling

Kondababu Kurakula , Xiao-Qing Sun , Chris Happé , Denielli da Silva Goncalves Bos , Robert Szulcek , et al.
European Respiratory Journal, 2019, 54 (3), pp.1802400. ⟨10.1183/13993003.02400-2018⟩
Journal articles inserm-02612640v1

[IL6R is the key therapeutical target in pulmonary arterial hypertension]

Ly Tu , Carole Phan , Marc Humbert , Christophe Guignabert
Médecine/Sciences, 2018, 34 (10), pp.765-768. ⟨10.1051/medsci/2018201⟩
Journal articles inserm-02580983v1
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T-cell costimulation blockade is effective in experimental digestive and lung tissue fibrosis

Gonçalo Boleto , Christophe Guignabert , Sonia Pezet , Anne Cauvet , Jérémy Sadoine , et al.
Arthritis Research & Therapy, 2018, 20 (1), pp.197. ⟨10.1186/s13075-018-1694-9⟩
Journal articles hal-03828440v1
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Neutralization of CXCL12 attenuates established pulmonary hypertension in rats Short Title: CXCL12 neutraligands in severe PH in the rat

Jennifer Bordenave , Raphaël Thuillet , Ly Tu , Carole Phan , Amélie Cumont , et al.
Cardiovascular Research, In press, pp.cvz153. ⟨10.1093/cvr/cvz153⟩
Journal articles hal-02195697v1
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Macrophage Migration Inhibitory Factor (MIF) Inhibition in a Murine Model of Bleomycin-Induced Pulmonary Fibrosis

Sven Günther , Jennifer Bordenave , Thông Hua-Huy , Carole Nicco , Amélie Cumont , et al.
International Journal of Molecular Sciences, 2018, 19 (12), pp.4105. ⟨10.3390/ijms19124105⟩
Journal articles inserm-02612651v1
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Nouveau regard sur la physiopathologie de l’hypertension artérielle pulmonaire

Jennifer Bordenave , Ly Tu , Laurent Savale , Alice Huertas , Marc Humbert , et al.
Revue des Maladies Respiratoires, 2019, 36 (4), pp.433-437. ⟨10.1016/j.rmr.2019.03.003⟩
Journal articles inserm-02454990v1
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Leptin and regulatory T-lymphocytes in idiopathic pulmonary arterial hypertension.

Alice Huertas , Ly Tu , Natalia Gambaryan , Barbara Girerd , Frédéric Perros , et al.
European Respiratory Journal, 2012, 40 (4), pp.895-904. ⟨10.1183/09031936.00159911⟩
Journal articles inserm-00913076v1
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Mineralocorticoid Receptor Antagonism by Finerenone Attenuates Established Pulmonary Hypertension in Rats.

Ly Tu , Raphaël Thuillet , Julie Perrot , Mina Ottaviani , Emy Ponsardin , et al.
Hypertension, 2022, pp.101161HYPERTENSIONAHA12219207. ⟨10.1161/HYPERTENSIONAHA.122.19207⟩
Journal articles inserm-03755156v1