The OnTheMove 2015 event held during October 26–30, in Rhodes, Greece, further consolidated the importance of this series of annual conferences that was started in 2002 in Irvine, California. It then moved to Catania, Sicily, in 2003, to Cyprus in 2004 and 2005, Montpellier in 2006, Vilamoura in 2007 and 2009, in 2008 to Monterrey, Mexico, to Heraklion, Crete, in 2010 and 2011, Rome in 2012, Graz in 2013, and Amantea, Italy, in 2014. This prime event continues to attract a diverse and relevant selection of today’s research worldwide on the scientific concepts underlying new computing paradigms, which of necessity must be distributed, heterogeneous, and supporting an environment of resources that are autonomous yet must meaningfully cooperate. Indeed, as such large, complex, and networked intelligent information systems become the focus and norm for computing, there continues to be an acute and even increasing need to address the implied software, system, and enterprise issues and discuss them face to face in an integrated forum that covers methodological, semantic, theoretical, and application issues as well. As we all realize, e-mail, the Internet, and even video conferences on their own are not optimal or even sufficient for effective and efficient scientific exchange.