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Journal Articles Chemical Communications Year : 2019

Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles

Abstract

We have developed new benign palladium nanoparticles able to catalyze the Suzuki-Miyaura cross-coupling reaction on human thyroglobulin (Tg), a naturally iodinated protein produced by the thyroid gland, in homogenates from patients' tissues. This represents the first example of a chemoselective native protein modification using transition metal nanoobjects in near-organ medium.
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Dates and versions

hal-03009700 , version 1 (02-12-2020)

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Arnaud Peramo, Anaëlle Dumas, Hynd Remita, Mireille Benoît, Stephanie Yen-Nicolay, et al.. Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles. Chemical Communications, 2019, 55, pp.15121 - 15124. ⟨10.1039/c9cc07803g⟩. ⟨hal-03009700⟩
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