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Article Dans Une Revue Angewandte Chemie International Edition Année : 2023

Novel Strategy to Drive the Intracellular Uptake of Lipid Nanoparticles for Photodynamic Therapy

Tiffany Ho
  • Fonction : Auteur
Keegan Guidolin
  • Fonction : Auteur
Michael Valic
  • Fonction : Auteur
Lili Ding
  • Fonction : Auteur
Jiachuan Bu
  • Fonction : Auteur
Mark Zheng
  • Fonction : Auteur
Miffy Cheng
  • Fonction : Auteur
Jeremy Yau
  • Fonction : Auteur
Juan Chen
Gang Zheng

Résumé

Abstract Nanoparticles’ uptake by cancer cells upon reaching the tumor microenvironment is often the rate‐limiting step in cancer nanomedicine. Herein, we report that the inclusion of aminopolycarboxylic acid conjugated lipids, such as EDTA‐ or DTPA‐hexadecylamide lipids in liposome‐like porphyrin nanoparticles (PS) enhanced their intracellular uptake by 25‐fold, which was attributed to these lipids’ ability to fluidize the cell membrane in a detergent‐like manner rather than by metal chelation of EDTA or DTPA. EDTA‐lipid‐incorporated‐PS (ePS) take advantage of its unique active uptake mechanism to achieve >95 % photodynamic therapy (PDT) cell killing compared to <5 % cell killing by PS. In multiple tumor models, ePS demonstrated fast fluorescence‐enabled tumor delineation within minutes post‐injection and increased PDT potency (100 % survival rate) compared to PS (60 %). This study offers a new nanoparticle cellular uptake strategy to overcome challenges associated with conventional drug delivery.

Domaines

Chimie

Dates et versions

hal-04271340 , version 1 (06-11-2023)

Identifiants

Citer

Tiffany Ho, Keegan Guidolin, Ali Makky, Michael Valic, Lili Ding, et al.. Novel Strategy to Drive the Intracellular Uptake of Lipid Nanoparticles for Photodynamic Therapy. Angewandte Chemie International Edition, 2023, 62 (16), ⟨10.1002/anie.202218218⟩. ⟨hal-04271340⟩
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